Chen P-Y, Huang BJ, Harris M, Boone C, Wang W, Carias H, Mesiona B, Mavrici D, Kohler A, Bollag G, Zhang C, Zhang Y, Shannon K. Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation. JCI Insight. 2023 Sep 8;8(17):e168445. doi: 10.1172/jci.insight.168445.

Levinson A, Tjoa K, Huang BJ, Meyer LK, Kim M-O, Brady SW, Zhang J, Shannon K, Wandler AM. Opposing Effects of KDM6A and JDP2 on Glucocorticoid Sensitivity in T-ALL. Blood Adv. 2023 Jul 25;7(14):3479-3484. doi: 10.1182/bloodadvances.2021006881.

Shannon K. The CCDI Comes Out of the Starting Block. J Clin Oncol. 2023 Jun 15;JCO2300652. doi: 10.1200/JCO.23.00652.

Blakeley JO and Shannon K. Precision Oncology for Papillary Craniopharyngioma. N Engl J Med. 2023 Jul 13;389(2):179-181. doi: 10.1056/NEJMe2305288.

Huang BJ and Shannon K. NFIA-ETO2, TP53, and erythroid leukemogenesis. Blood. 2023 May 4;141(18):2168-2170. doi: 10.1182/blood.2023019856.

Popescu B and Shannon K. Sidestepping SHP2 inhibition. J Exp Med. 2023 May 1;220(5):e20230082. doi: 10.1084/jem.20230082.

Remsberg JR, Suciu RM, Zambetti NM, Hanigan TW, Firestone A, Inguva A, Long A, Ngo N, Lum KM, Henry CL, Richardson SK, Predovic M, Huang BJ, Howell AR, Niphakis MJ, Shannon K, and Cravatt BF. ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth. Nat Chem Biol. 2021 Apr 29. doi: 10.1038/s41589-021-00785-8.

Wong JC, Perez-Mancera PA, Huang TQ, Kim J, Grego-Bessa J, del pilar Alzamora M, Kogan SC, Sharir A, Keefe SH, Morales C, Schanze D, Zenker M, Sheppard D, Klein OD, Tuveson DA, Braun BS*, Shannon K*. KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice. JCI Insight. 2020 Nov 5;5(21):e140495. doi: 10.1172/jci.insight.140495.

Wandler AM, Huang BJ, Craig J, Hayes K, Yan H, Meyer LK, Scacchetti A, Monsalve G, Dail M, Li Q, Wong JC, Weinberg O, Hasserjian RP, Kogan SC, Jonsson P, Yamamoto K, Sampath D, Nakitandwe J, Downing JR, Zhang J, Aster J, Taylor BS, Shannon K. Loss of glucocorticoid receptor expression mediates dexamethasone resistance in T-cell acute lymphoblastic leukemia. Leukemia 2020; 34: 2025-2037.

Zambetti NA, Firestone AJ, Remsberg JR, Huang BJ, Wong JC, Long AM, Predovic M, Suciu RM, Inguva A, Kogan SC, Haigis KM, Cravatt BF, Shannon K. Genetic disruption of N-RasG12D palmitoylation perturbs hematopoiesis and prevents myeloid transformation in mice. Blood 2020; 135:1772-178.

Pucciarelli D, Angus SP, Huang BJ, Zhang C, Nakaoka HJ, Krishnamurthi G, Bandyopadhyay S, Clapp DW, Shannon K, Johnson GL, Nakamura JL. Nf1 mutant tumors undergo transcriptome and kinome re-modeling after inhibition of either mTOR or MEK. Mol Cancer Ther. 2020; molcanther.1017.2019.doi: 10.1158/1535-7163.MCT-19-1017.

Meyer LK, Huang BJ, Delgado-Martin C, Roy R, Hechmer, WandlerAM, Vincent TL, Fortina P, Olshen AB, Wood BL, Horton TH, Shannon KM, Teachey DT, Hermiston ML. Glucocorticoids paradoxically facilitate steroid resistance in subsets of T-cell acute lymphoblastic leukemias and normal thymocytes. J Clin Invest. 2020 Jan 13. pii: 130189.

Huang BJ, WandlerAM, Meyer LK, DailM, Daemen A, Sampath D, Li Q, Wang X, WongJC, Nakitandwe J, DowningJR, Zhang J, Taylor BS, Shannon K. Convergent genetic aberrations in murine and human T lineage acute lymphoblastic leukemias. PLoS Genetics 2019; 15:e1008168.

Bielski CM, Donoghue MTA, Gadiya M, Won HH, Chang MT, Jonsson P, Penson A, Harris C, Schram AM, Syed A, Zehir A, Chapman PB, Hyman DM, Solit DB, Shannon K, Chandarlapaty S, Berger MF, Taylor BS. Widespread selection for oncogenic mutant allele imbalance in cancer. Cancer Cell 2018; 34: 1-11.

Wong JC, Bryant V, Lamprecht T, Ma J, Walsh M, Schwartz J, Del Pilar Alzamora M, Mullighan CG, Loh ML, Ribeiro R, Downing JR, Carroll WL, Davis J, Gold S, Rogers PC, Israels S, Yanofsky R, Shannon K, Klco JM. Germline SAMD9 and SAMD9L mutations are associated with extensive genetic evolution and diverse hematologic outcomes. JCI Insight. 2018 Jul 26;3(14).

Burgess MR, Hwang E, Mroue R, Bielski CM, Wandler AM, Huang BJ, Firestone AJ, Young A, LaCap JA, Crocker L, Asthana S, Davis, EM, Xu J, Akagi K, Le Beau MM, Li Q, Haley B, Stokoe D, Sampath D, Taylor BS, Evangelista M*, Shannon K*. KRAS allelic imbalance enhances fitness and modulates MAP kinase dependence In KRAS mutant cancers. Cell 2017 Feb 23;168(5):817-829.e15. * - Corresponding authors.